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KMID : 0356419950130010007
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Journal of Korean Andrology
1995 Volume.13 No. 1 p.7 ~ p.12
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Cavernosal Response to Nonadrenergic-Noncholinergic Stimulation Compared with Response to Exogenous Nitric Oxide
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Abstract
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Nitric oxide (NO) has been known to be endothelium-derived relaxing factor (EDRF) and the nonadrenergic-noncholinergic (NANC) neurotransmitter involved in the relaxation of cavernous smooth muscle. This study was initiated to characterize NANC
neurotransmission after electrical field stimulation (EFS) in compared with exogenous NO administration. Using an organ bath, isometric tension measurements were made in strips of rabbit corpus cavernous smooth muscle. The relaxation response
elicited
by exogenous NO was very similar to that evoked by EFS via the NANC pathway. The relaxant responses to NANC neurotransmission after EFS were almost abolished by NO synthase inhibitor NG-nitro-L-arginine (L-NOARG) (100μM) (p<0.001), and were
significantly inhibited by oxyhemoglobin (100μM) which has a high binding affinity for NO in the extracellular compartment (p<0.025). Relaxation of corpus cavernosum in response to exogenous NO was almost abolished by oxyhemoglobin (100μM)
(p<0.001)
but was not influenced by L-NOARG (100μM).
Our findings suggest that NO is a potent relaxant of rabbit cavernous smooth muscle via NANC neurotransmission by EFS. Endogenous No is the principal mediator of penile erection caused by NANC stimulation.
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